Nuclear Physics and Atomic Energy

ядерна ф≥зика та енергетика
Nuclear Physics and Atomic Energy

  ISSN: 1818-331X (Print), 2074-0565 (Online)
  Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine
  Languages: Ukrainian, English, Russian
  Periodicity: 4 times per year

  Open access peer reviewed journal


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Nucl. Phys. At. Energy 2015, volume 16, issue 2, pages 164-168.
Section: Radiobiology and Radioecology.
Received: 07.04.2015; Accepted: 11.06.2015; Published online: 20.07.2015.
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Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma

N. M. Ryabchenko, O. B. Ganzha*, M. O. Druzhyna

Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

*Corresponding author. E-mail address: olganzha@ukr.net

Abstract: Effects of prolonged fractionated ionized radiation in low doses on the growth and metastasis intensity of mice Lewis lung carcinoma (LLC) are studied. On the background of tumor growth, stimulation induced by irradiation in the selected mode of dose fractionation inhibition of spontaneous dissemination of tumor cells into lungs is observed. On the 23-rd day after cell inoculation metastases incidence in irradiated animals was 25 % lower; the number and size of lung metastases decreased by 1.6 and 1.7 times. In the remote terms of tumor growth inhibition of functional activity of macrophages Ц central effectors of non-specific anti-tumor immunity was revealed.

Keywords: low dose ionizing radiation, mice Lewis lung carcinoma, nonspecific antitumor immune response.

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