Nuclear Physics and Atomic Energy

ядерна ф≥зика та енергетика
Nuclear Physics and Atomic Energy

  ISSN: 1818-331X (Print), 2074-0565 (Online)
  Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine
  Languages: Ukrainian, English, Russian
  Periodicity: 4 times per year

  Open access peer reviewed journal

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Nucl. Phys. At. Energy 2015, volume 16, issue 2, pages 164-168.
Section: Radiobiology and Radioecology.
Received: 07.04.2015; Accepted: 11.06.2015; Published online: 20.07.2015.
PDF Full Text (ua)

Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma

N. M. Ryabchenko, O. B. Ganzha*, M. O. Druzhyna

Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

*Corresponding author. E-mail address:

Abstract: Effects of prolonged fractionated ionized radiation in low doses on the growth and metastasis intensity of mice Lewis lung carcinoma (LLC) are studied. On the background of tumor growth, stimulation induced by irradiation in the selected mode of dose fractionation inhibition of spontaneous dissemination of tumor cells into lungs is observed. On the 23-rd day after cell inoculation metastases incidence in irradiated animals was 25 % lower; the number and size of lung metastases decreased by 1.6 and 1.7 times. In the remote terms of tumor growth inhibition of functional activity of macrophages Ц central effectors of non-specific anti-tumor immunity was revealed.

Keywords: low dose ionizing radiation, mice Lewis lung carcinoma, nonspecific antitumor immune response.


1. L.M. Martin, B. Marples, T.H. Lynch et al. Exposure to low dose ionising radiation: Molecular and clinical consequences. Cancer Lett. 338(2) (2013) 209.

2. L. Feinendegen. Evidence for beneficial low level radiation effects and radiation hormesis. Br. J. Radiol. 78 (2005) 3.

3. Y. Hosoi, K. Sakamoto. Suppressive effect of low dose total body irradiation on lung metastasis: dose dependency and effective period. Radiother. Oncol. 26 (1993) 177.

4. A. Cheda, J. Wrembel-Wargocka, E. Lisiak. Single Low Doses of X-Rays Inhibit the Development of Experimental Tumor Metastases and Trigger the Activities of NK Cells in Mice. Radiat. Res. 161 (2004) 335.

5. B.R. Scott, V.R. Bruce, K.M. Gott et al. Small γ-Ray Doses Prevent Rather than Increase Lung Tumors in Mice. Dose Response 10(4) (2012) 527.

6. Anticancer Drug Development Guide. Preclinical Screening, Clinical Trials, and Approval, 2-nd ed. Ed. by B.A. Teicher and P.A. Andrews (Totowa - New Jersey: Humana Press, 2004) 450 p.

7. A.G. Goncharov, I.S. Freydlin, V.S. Smirnov et al. Foundations of Clinical Immunology and Methodological Approaches to Estimation of Immune Status, Ed. by M.G. Romantseva (Kaliningrad: Kaliningradskiy Universitet, 1997) 73 p. (Rus)

8. S.I. Liochev, I. Fridovich. Lucigenin (Bis-N-methylacridinium) as a Mediator of Superoxide Anion Production. Archives of Biochemistry and Biophysics 337(1) (1997) 115.

9. B.I. Gerashchenko, N.M. Ryabchenko, O.A. Glavin et al. Fractionated low-dose radiation exposure potentiates proliferation of implanted tumor cells. Experimental Oncology 35(1) (2013) 69. Article

10. I. Pogribny, I. Koturbash, V. Tryndyak et al. Fractionated Low-Dose Radiation Exposure Leads to Accumulation of DNA Damage and Profound Alterations in DNA and Histone Methylation in the Murine Thymus. Mol. Cancer Res. 3 (2005) 553.

11. E.M. Nowosielska, A. Cheda, J. Wrembel-Wargocka Anti-neoplastic and immunostimulatory effects of low-dose X-ray fractions in mice. Int. J. Rad. Biol. 87 (2011) 202.