Nuclear Physics and Atomic Energy

ядерна ф≥зика та енергетика
Nuclear Physics and Atomic Energy

  ISSN: 1818-331X (Print), 2074-0565 (Online)
  Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine
  Languages: Ukrainian, English, Russian
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Nucl. Phys. At. Energy 2015, volume 16, issue 4, pages 374-380.
Section: Radiobiology and Radioecology.
Received: 15.05.2015; Accepted: 10.12.2015; Published online: 12.02.2016.
PDF Full text (ua)

Hematological parameters for a single oral intake of sodium iodide (Na131I) to the body of experimental rats

T. V. Tsyganok1,*, N. K. Rodionova2, I. P. Drozd1, L. V. Tarasenko1, V. I. Fedorchenko1

1 Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine
2 R. Kavetsky Institute for Experimental Pathology, Oncology & Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

*Corresponding author. E-mail address:

Abstract: Study of hematological parameters (number of erythrocytes, leukocytes and leukogram) of peripheral blood of laboratory Wistar rats after administration of single oral radionuclide 131I in a solution of sodium iodide (Na131I) with activities of 3.3, 19.16, 113.8 and 327.0 kBq per animal was performed. Number of red blood cells in the bloodstream throughout the observation period was not significantly changed. Number of white blood cell count increased. The increase of activity injected by radioiodine caused reliably greater degree of significant increase in the number of leukocytes throughout the experiment due to increase of the absolute number of lymphocytes.

Keywords: laboratory rats, 131≤, peripheral blood, leukocytes, leukogram.


1. V.G. Bebeshko, I.S. Dyagil', S.V. Klimenko et al. Hematologic effects in the early and distant periods after the Chernobyl accident. In: Medical Consequences of the Accident on the Chornobyl NPP . Eds. O.F. Voziyanov, V.G. Bebeshko, D.A. Bazyka (Kyiv: DIA, 2007) p. 327. (Ukr)

2. Ya.I. Serkiz, A.I. Lypska, I.P. Drozd, N.K. Rodionova. Radiobiological effects in mammals: 20 years view after the Chernobyl accident. Visnyk NAN Ukrayiny 4 (2006) 14. (Ukr) Article

3. K.N. Muksinova, L.D. Murzina, V.S. Voronin, V.V. Sukhodoev. The modification of the cells content in the lymphoid tissue during the chronic action of tritium oxide and external γ-radiation of 137Cs. Radiobiologiya 5 (1981) 737. (Rus)

4. I.Z. Borbulyak, N.K. Rodionova, N.M. Bilko. Complex assessment of the hematopoietic system state of laboratory animals under internal irradiation with strontium. Problemy Radiatsiinoyi Medytsyny ta Radiobiologiyi 17 (2012) 359. (Ukr) Article

5. N.K. Rodionova, N.P. Atamanyuk, L.P. Derevyanko et al. Hematological effects in combined action of external and internal irradiation of experimental animals. Problemy Radiatsiinoyi Medytsyny ta Radiobiologiy 17 (2012) 401. (Ukr) Article

6. A.M. Lyaginskaya, V.A. Osipov. Short-lived iodine (131-135) isotopes in the conditions of a radiation accident: the features of formation and distribution of absorbed doses in the thyroid gland, biological effects. Med. Radiologiya i Radiatsionnaya Bezopasnost 50(2) (2005) 18. (Rus) Article

7. Yu.A. Klassovskij, I.Ya. Vasilenko, M.F. Terekhov. Methods and results of the equivalent dose assessment of the thyroid gland of experimental animals and humans with various iodine isotopes and their. In: Radiobiology Experiment and Man. Ed. by Yu.I. Moskalev (Moskva: Meditsina, 1970) p. 134. (Rus).

8. G.K. Korolev, I.V. Zhukova. To the question of 131≤ biological action. In: Radiobiology Experiment and Man. Ed. by Yu. I. Moskalev (Moskva: Atomizdat, 1970) p. 174. (Rus)

9. O.A. Sova, I.P. Drozd. Dose formation and hematologic effects with prolonged internal exposure of rats by isotope 131I. Yaderna Fizyka ta Energetyka (Nucl. Phys. At. Energy) 15(4) (2014) 359. (Ukr) Article

10. L.P. Andreeva, P.V. Goloshchapov. Quantitative and qualitative changes in the hematopoietic system of animals under combined action of different tropicity nuclides. In: Radioecology of Animals (Moskva: Nauka, 1977) 221 p. (Rus)

11. O.S. Monastyrska. In: Clinical Laboratory Tests (Vinnytsya: Nova Knyga, 2007) p. 14. (Ukr)

12. V.M. Zaporozhan, V.K. Napkhanyuk, N.O. Goryanova et al. The Morphology of Blood Cells of Laboratory Animals and Humans (Odessa: Odessa State Medical University, 2002) 118 p. (Ukr)

13. N.P. Zapadnyuk, V.I. Zapadnyuk, E.A. Zakhariya, B.V. Zapadnyuk. Laboratory Animals. Breeding, Maintenance, Use in the Experiment (Kyiv: Vyshcha Shkola, 1983) 383 p. (Rus)

14. N.A. Zapolskaya, A.V. Fedorova, L.N. Lavrentev et al. Biological Effects of Radionuclides (Moskva: Atomizdat, 1976) 254 p. (Rus)

15. N.G. Yakovleva. Effect of incorporated radionuclides and external irradiation on peripheral blood. In: Radiation Hygiene (Leningrad: LenNIIRG, 1980) 97 p. (Rus)

16. A.V. Fedorova, N.G. Yakovleva, Khr. Nechev. The effect of individual radionuclides on hematologic and biochemical blood indicators. Rentgenologiya i Radiologiya (Sofiya) 14(2) (1975) 12. (Rus)