Nuclear Physics and Atomic Energy


Nuclear Physics and Atomic Energy

  ISSN: 1818-331X (Print), 2074-0565 (Online)
  Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine
  Languages: Ukrainian, English, Russian
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Nucl. Phys. At. Energy 2015, volume 16, issue 4, pages 389-398.
Section: Radiobiology and Radioecology.
Received: 07.08.2015; Accepted: 10.12.2015; Published online: 12.02.2016.
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https://doi.org/

Mathematical analysis of functional properties alterations of mice bone marrow during protracted external irradiation with different dose rate intensity

R. V. Boiko, D. I. Bilko, I. Z. Russu, N. M. Bilko*

National University Kyiv-Mohyla Academy, Kyiv, Ukraine

*Corresponding author. E-mail address: nbilko@ukma.kiev.ua

Abstract: Using developed mathematical model together with the experimental results concerning protracted continuous irradiation influence in the doses 0.01, 0.03, 0.06, 0.1, 0.25, 0.5 and 0.8 Gy/day (23 h per day), as well as 1, 3, 6 and 10 Gy/day (24 h) on the alterations in colony-forming units (CFU) number of mice bone marrow we defined the mechanism of new steady-state regime of CFU number forming during irradiation; CFU stabilization level is assessed depending on everyday irradiation dose rate. As a result of experiment we have determined parameters characterizing the reaction of hematopoietic system to CFU loss after everyday irradiation with different dose rate intensity. Quantitative indices are established, showing the decrease of CFU income intensity from the sources to bone marrow, when everyday irradiation dose rate increases.

Keywords: ionizing radiation, bone marrow, functional properties, mathematical modeling.

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