Nuclear Physics and Atomic Energy

Nuclear Physics and Atomic Energy

  ISSN: 1818-331X (Print), 2074-0565 (Online)
  Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine
  Languages: Ukrainian, English, Russian
  Periodicity: 4 times per year

  Open access peer reviewed journal

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Nucl. Phys. At. Energy 2019, volume 20, issue 2, pages 178-186.
Section: Radiobiology and Radioecology.
Received: 26.02.2019; Accepted: 17.04.2019; Published online: 27.08.2019.
PDF Full text (ua)

Hematological and cytogenetic effects in the offspring of laboratory rats exposed to incorporated 131I

. B. Ganzha1,*, N. M. Riabchenko1,, . . Lypska1, N. . Rodionova1, V. V. Talko2

1 Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine
2 State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine

*Corresponding author. E-mail address:

Abstract: Investigations of peripheral blood counts and bone marrow cytogenetic parameters of laboratory white male rats, descendants of the animals treated with incorporated 131I, were carried out. According to the established experimental model, sodium iodide was administered to male and female rats (parents of the first generation offspring) with the activity of 27.35 kBq per animal. Patterns and features of alterations in the hematopoietic system found in the rat first generation offspring are discussed.

Keywords: laboratory rats, 131, first generation offspring, peripheral blood, bone marrow, hematological and cytogenetic parameters.


1. D. Bazyka (ed.) et al. Health Effects of the Chornobyl Accident Thirty Years Aftermath (Kyiv: DIA, 2016) 524 p.

2. V.G. Baryachtar. Assessing the scope of the catastrophe. In: Chornobyl Catastrophe. Ed. V.G. Baryakhtar (Kyiv: Export Publishing House, 1997) p. 24.

3. Ye. Stepanova et al. Early and late consequences in children evacuated from the 30-km zone and residents of radiation contaminated area. In: Health Effects of the Chornobyl Accident a Quarter of Century Aftermath (Kyiv: DIA, 2011) p. 591.

4. M.M. Korenev, V.I. Kovaleva, N.V. Bagatskaya. linical, genealogical and cytogenetic peculiarties of children born from fathers liquidators of the Chernobyl accident. Int. J. Radiat. Med. 6 (2004) 78.

5. ICRP Publication 88. Doses to the Embryo and Fetus from Intakes of Radionuclides by the Mother. Ann. ICRP 31 (2001) 19.

6. ICRP Publication 84. Pregnancy and Medical Radiation. Ann. ICRP 30 (2000) 1.

7. ICRP Publication 90. Biological Effects after Prenatal Irradiation (Embryo and Fetus). Ann. ICRP 33 (2003) 1.

8. I.P. Drozd et al. Patent No. 113045 UA. Method of determining the absorbed dose from the incorporated 131I on the thyroid gland of the fetus of laboratory rats. Institute for Nuclear Research, National Academy of Sciences of Ukraine; State Enterprise "National Scientific Center of Radiation Medicine of the National Academy of Medical Sciences of Ukraine". Published by 10.01.2017; Bull No. 1. (Ukr)

9. O.S. Monastyrska. Clinical Laboratory Studies. Ed. M.B. Shegedin (Vinnitsa: Nova knyga, 2007) 165 p. (Ukr)

10. K. Criswell et al. Validation of a flow cytometric acridine orange micronuclei methodology in rats. Mutat Res. 528 (2003) 1.

11. C. Riccardi, I. Nicoletti. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nature Prot. 1 (2006) 1458.

12. J. Palis et al. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development 126 (1999) 5073.

13. J. Feldman, J. Vazquez, S. Kurtz. Maturation of the rat fetal thyroid. J. Biophys. Biochem. Cytol. 11 (1961) 365.

14. V.V. Talko et al. Long-term radiobiological effects in rats after exposure of 131I in utero. Yaderna Fizyka ta Energetyka (Nucl. Phys. At. Energy) 18 (2017) 350. (Ukr)

15. V.M. Zaporozhan et al. Morphology of Blood Cells of Laboratory Animals and Humans: Atlas (Odessa: Odessa State Medical University, 2002) 118 p. (Ukr) Book

16. O.A. Pakhrova et al. Leukocyte blood indices when adapting to acute experimental hypoxia of the brain, depending on the level of stress tolerance. Sovremennyye Problemy Nauki i Obrazovaniya 6 (2016)

17. T. Nomura et al. Transgenerational effects of radiation on cancer and other disorders in mice and humans. J. Radiat. Cancer. Res. 8 (2017) 123.

18. Y.E. Dubrova. Radiation-induced transgenerational instability. Oncogene 22 (2003) 7087.

19. Ye.M. Prokhorova. Investigation of mutagenic effects in the offspring of rats born from parents who have undergone the action of incorporated 131I. Scientific papers of the Petro Mohyla Black Sea Nat. Univ. Ser. "Technogenic Safety. Radiobiology" 289 (2017) 136. (Ukr)