Nuclear Physics and Atomic Energy


Nuclear Physics and Atomic Energy

  ISSN: 1818-331X (Print), 2074-0565 (Online)
  Publisher: Institute for Nuclear Research of the National Academy of Sciences of Ukraine
  Languages: Ukrainian, English
  Periodicity: 4 times per year

  Open access peer reviewed journal


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Nucl. Phys. At. Energy 2021, volume 22, issue 2, pages 174-181.
Section: Radiobiology and Radioecology.
Received: 23.07.2020; Accepted: 19.07.2021; Published online: 10.09.2021.
PDF Full text (ua)
https://doi.org/10.15407/jnpae2021.02.174

Effects of genomic instability in populations of Drosophilae melanogaster from regions of Ukraine with different radiation impact factors

A. P. Kravets*, D. A. Sokolova, N. L. Kovalchuk

Institute of Cell Biology and Genetic Engineering of the National Academy of Sciences of Ukraine, Kyiv, Ukraine

*Corresponding author. E-mail address: kaplibra@gmail.com

Abstract: Differences in the gonadal dysgenesis frequency as an indicator of the activation of mobile elements were revealed in F1-descendants of natural populations of Drosophla melanogaster, selected from regions of different radiation impact. Under conditions of additional low-rate chronic irradiation in laboratory conditions for 10 generations, significant differences in changes in the level and dynamics of this indicator were established depending on the accumulated dose of Drosophila populations from the city of Netishin (Khmelnytskyi NPP) and Magarach city.

Keywords: mobile elements, gonadal dysgenesis, genomic instability, dynamic effects of chronic exposure.

References:

1. I.I. Pelevina et al. Genome instability after exposure to low doses of radiation (in the 10-kilometer zone of the Chernobyl accident and in laboratory conditions). Radiation Biology. Radioecology 36 (1996) 546. (Rus)

2. I.I. Suskov, I.S. Kuzmina. Polygenic realization of mutagenic effects in the body of people exposed to radiation in low doses. Radiation Biology. Radioecology 41(5) (2001) 606. (Rus)

3. N.S. Kuzmina, I.I. Suskov. Expression of genomic instability in lymphocytes of children living under conditions of prolonged exposure to radiation factors. Radiation Biology. Radioecology 42 (2002) 735. (Rus)

4. K. N. Dancause et al. Chronic radiation exposure in the Rivne-Polissia region of Ukraine: Implications for birth defects. American Journal of Human Biology 22 (2010) 667. https://doi.org/10.1002/ajhb.21063

5. S.M. de Toledo et al. Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells. Int. J. Radiat. Biol. 93 (2017) 1182. https://doi.org/10.1080/09553002.2017.1334980

6. L. Fang et al. Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X Rays in Northern China. Dose Response 17 (2019) 1559. https://doi.org/10.1177/1559325819891378

7. Z. Siama et al. Chronic low dose exposure of hospital workers to ionizing radiation leads to increased micronuclei frequency and reduced antioxidants in their peripheral blood lymphocytes. Int. J. Radiat. Biol. 95 (2019) 697. https://doi.org/10.1080/09553002.2019.1571255

8. ICRP, 2007. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Ann. ICRP 37(2-4) (2007). https://journals.sagepub.com/toc/anib/37/2-4

9. L. Dobrzyński et al. Cancer Mortality Among People Living in Areas with Various Levels of Natural Background Radiation. Dose Response 13 (2015) 2391. https://doi.org/10.1177/1559325815592391

10. M.D. Golubovsky. Century of Genetics: Evolution of Ideas and Concepts (St.-Petersburg: Borey Art, 2000) 262 p. (Rus)

11. V.G. Zainullin. Mutability of natural populations and laboratory lines of Drosophila under conditions of chronic irradiation in low doses of low intensity. Radiation Biology. Radioecology 36(4) (1996) 561. (Rus)

12. I.A. Kozeretskaya et al. Mutation processes in natural populations of Drosophila and Hirindo rustica from the radioactively contaminated territory of Ukraine. Cytology and Genetics 4 (2008) 63. (Rus) https://doi.org/10.3103/S0095452708040099

13. A.P. Kravets, T.A. Musseaut, J.A. Omelchenko. Dynamics of the frequency of hybrid dysgenesis of Drosophlae melanogaster under controlled conditions of chronic exposure. Radiation Biology. Radioecology 49 (2009) 683. (Rus)

14. V.N. Novoseltsev. Control Theory and Biosystems: Analysis of Protection Properties (Moskva: Nauka, 1978) 314 p. (Rus) Google books

15. E.B. Burlakova et al. Features of the biological effect of small doses of radiation. Radiation Biology. Radioecology 39 (1999) 26. (Rus)

16. I.K. Kolomiytseva. Non-monotonicity of the dose-effect relationship in the region of low doses of ionizing radiation. Radiation Biology. Radioecology 43 (2003) 179. (Rus)

17. A.P. Kravets, G.D. Gatilova, D.M. Grodzinsky. Dynamics of the release of cytogenetic anomalies in the seedling meristem under chronic seed irradiation. Radiation Biology. Radioecology 48 (2008) 208. (Rus)

18. J.A. Law, S.E. Jacobsen. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nature Reviews Genetics 11 (2010) 204. https://doi.org/10.1038/nrg2719

19. E. Yushkova, V. Zainullin. Interaction between gene repair and mobile elements-induced activity systems after low-dose irradiation. Int. J. Radiat. Biol. 92 (2016) 485. https://doi.org/10.1080/09553002.2016.1206221

20. A.A. Moiseev, V.I. Ivanov. Dosimetry and Radiation Hygiene Handbook. (Moskva: Energoatomizdat, 1990) 243 p. (Rus) Google books

21. V.A. Bazhenov et. al. Harmful Chemicals. Radioactive Substances (Leningrad: Chemistry: Leningrad department, 1990) 463 p. (Rus) Google books