 |
ßäåðíà ô³çèêà òà åíåðãåòèêà
ISSN:
1818-331X (Print), 2074-0565 (Online) |
| Home page | About |
Full text (ua) Inductive hyperthermia planning for patients with breast cancer metastasis to lymph nodes
O. I. Mokhonko1, V. E. Orel2,3,*, I. I. Smolanka (Sr.)2, L. A. Syvak2, A. D. Loboda2, I. V. Dosenko2, A. O. Lyashenko2, I. I. Smolanka (Jr.)2, O. Yu. Rykhalskyi2, V. B. Orel2,3, O. I. Dasyukevich2, T. Ye. Tarasenko2, S. I. Vovyanko3
1 Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
2 National Cancer Institute, Kyiv, Ukraine
3 National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", Kyiv, Ukraine
*Corresponding author. E-mail address:
valeriiorel@gmail.com
Abstract: Inductive hyperthermia treatment plans were built using Comsol Multiphysics software for patients with breast cancer metastasis to lymph nodes. To assess the influence of electromagnetic irradiation on temperature increase in metastatic lymph nodes, treatment plans were based on moderate hyperthermia parameters (< 42 °C). The proposed technology can be used to provide a more personalized approach to treatment planning for patients with locally advanced breast cancer receiving combination therapy which involves neoadjuvant chemotherapy and expand eligibility for organ-preserving surgery.
Keywords: inductive hyperthermia, breast cancer, metastasis, lymph nodes, computer planning.
References:1. Z.P. Fedorenko et al. Cancer in Ukraine, 2016 - 2017. Incidence, mortality, prevalence, and other relevant statistics. Bull. of the Nat. Cancer Registry of Ukraine 19 (2018) 44. (Ukr) http://www.ncru.inf.ua/publications/BULL_19/PDF/44-45%20mol.pdf
2. R.L. Siegel, K.D. Miller, A. Jemal. Cancer statistics, 2019. CA Cancer J. Clin. 69(1) (2019) 7. http://doi.org/10.3322/caac.21551
3. Z.P. Fedorenko et al. Cancer in Ukraine, 2018 - 2019. Incidence, mortality, prevalence, and other relevant statistics. Bull. of the Nat. Cancer Registry of Ukraine 21 (2020) 55. (Ukr) http://www.ncru.inf.ua/publications/BULL_21/PDF/mol.pdf
4. E. Panieri, M.M. Santoro. ROS homeostasis and metabolism: a dangerous liason in cancer cells. Cell Death & Disease 7 (2016) e2253. https://doi.org/10.1038/cddis.2016.105
5. M. Erbes et al. Hyperthermia-driven aberrations of secreted microRNAs in breast cancer in vitro. Int. J. Hyperthermia 32(6) (2016) 630. https://doi.org/10.3109/02656736.2016.1161832
6. F. Chen et al. Hyperthermia in combination with oxidative stress induces autophagic cell death in HT-29 colon cancer cells. Cell Biol. Int. 32(7) (2008) 715. https://doi.org/10.1016/j.cellbi.2008.02.010
7. M.W. Dewhirst, C.T. Lee, K.A. Ashcraft. The future of biology in driving the field of hyperthermia. Int. J. Hyperthermia 32(1) (2016) 4. https://doi.org/10.3109/02656736.2015.1091093
8. Y. Yorozu et al. Electron spectroscopy studies on magnetooptical media and plastic substrate interface. IEEE Transl. J. Magn. Japan 2(8) (1987) 740. https://doi.org/10.1109/TJMJ.1987.4549593
9. Introduction to COMSOL Multiphysics. Version COMSOL 5.4. (COMSOL Grîup, 2018) 216 p. https://cdn.comsol.com/doc/5.4/IntroductionToCOMSOLMultiphysics.ru_RU.pdf
10. A.G. Losev et al. Problems of measurement and modeling of thermal and radiation fields in biological tissues: analysis of microwave thermometry data. Vesti Volgogradskogo Gosudarstvennogo Universiteta 6 (2015) 31. (Rus) http://dx.doi.org/10.15688/jvolsu1.2015.6.3
11. F. Bardati, S. Iudicello. Modeling the visibility of breast malignancy by a microwave radiometer. IEEE Transactions on Biomedical Engineering 55(1) (2008) 214. https://doi.org/10.1109/TBME.2007.899354
12. A. Loboda et al. Efficacy of combination neoadjuvant chemotherapy and regional inductive moderate hyperthermia in the treatment of patients with locally advanced breast cancer. Technol. Cancer Res. Treat. 19 (2020) 1533033820963599. https://doi.org/10.1177/1533033820963599
13. A.I. Costin et al. Intraoperative assessment of sentinel lymph nodes in early-stage breast cancer. Rom. J. Morphol. Embryol. 59(4) (2018) 1033. https://europepmc.org/article/med/30845281